Antimicrobial Activity of Polyphenolic Compounds
Introduction. The emergence of new strains of microorganisms with multidrug resistance (MDR) is one of the most pressing problems of modern medicine. Currently, to combat MDR, active attempts are being made to obtain new biologically active substances of natural (microbial, plant, animal) origin. Ea...
| Published in: | Drug development & registration |
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| Main Authors: | , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2022
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| Subjects: | |
| Online Access: | https://doi.org/10.33380/2305-2066-2022-11-2-65-72 https://doaj.org/article/3671f0a19211408bbec9a8171ac0f48d |
| Summary: | Introduction. The emergence of new strains of microorganisms with multidrug resistance (MDR) is one of the most pressing problems of modern medicine. Currently, to combat MDR, active attempts are being made to obtain new biologically active substances of natural (microbial, plant, animal) origin. Earlier, 32 individual compounds were isolated by the authors from the aerial part of Iris laclea Pall., Rubus chameamorus L. leaves, Empetrum nigrum L. shoots, Ononis arvensis L. aerial part and Solidago canadensis L. aerial part, and 2 more compounds were synthesized according to previously published methods. The study of the antimicrobial activity of compounds of these classes is an urgent problem for finding potential agents for combating MDR.Aim. Studying of the antimicrobial activity of the isolated and synthesized substances in an individual form against Staphylococcus aureus, Escherichia coli and Candida albicans.Materials and methods. To test the antimicrobial activity, substances of 34 compounds were used, which were obtained as a result of previous research, the structure of which were established using NMR spectroscopy and high-resolution mass spectrometry. The antifungal and antibacterial activity of the compounds were determined through the micromethod of two-fold serial dilutions in liquid nutrient medium in 96-well plates in duplicate. Screening for antimicrobial activity was carried out against reference (type) strains of Staphylococcus aureus ATCC 6538-P, Escherichia coli ATCC 25922, Candida albicans NCTC 885-653.Results and discussion. In the group of flavonoids and O-, C-glycosides, the antifungal activity of all studied compounds did not differ significantly, but it should be noted that the antibacterial activity of apigenin C-glycosides and isoflavonoid O-glycosides was slightly greater in comparison to O-glycosides of flavonols. The greatest antimicrobial activity among the group of chalcones was shown directly by the chalcones themselves – chalcone, 2’, 4’-dihydroxychalcone, and ... |
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