Disseminated toxoplasmosis presenting as sepsis in two AIDS patients Toxoplasmose disseminada sepse símile em dois pacientes com AIDS

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Carlos José Dornas Gonçalves Barbosa, Rodrigo Juliano Molina, Murilo Barcelos de Souza, Ana Cristina A. Silva, Adilha Rua Micheletti, Marlene Antonia dos Reis, Vicente de Paula Antunes Teixeira, Mario León Silva-Vergara
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2007
• Subjects: AIDS; Acute disseminated toxoplasmosis; Sepsis; Toxoplasma gondii; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Aguda; Arctic
• Online Access: https://doi.org/10.1590/S0036-46652007000200009; https://doaj.org/article/331ecf5884864ffe904da171bfc3c1f7

This report describes two patients who presented acute disseminated and severe toxoplasmosis as the first opportunistic disease related to acquired immunodeficiency syndrome. At admission, clinical and laboratory findings were similar to sepsis or septic shock and a fast evolutive course to death occurred in both cases. At necropsy, an inflammatory reaction and presence of a great number of Toxoplasma gondii cysts and tachyzoites were observed in most organs examined. O presente relato descreve dois pacientes que apresentaram toxoplasmose aguda, disseminada e grave como primeira manifestação oportunista da síndrome da imunodeficiência adquirida. Os achados clínicos e laboratoriais foram similares aos de sepse ou choque séptico e, em ambos os casos houve evolução rápida para óbito. À necropsia, foi observada reação inflamatória e presença de taquizoítos e cistos de Toxoplasma gondii na maioria dos órgãos examinados.