Evolutionary history of Plasmodium vivax and Plasmodium simium in the Americas

Abstract Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. Plasmodium vivax is the most prevalent human-infecting species in the Americas. However, the origins of this parasite in this continent are still debated. Similarly, it is now accepted that the existenc...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Virginie Rougeron, Josquin Daron, Michael C. Fontaine, Franck Prugnolle
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2022
Subjects:
Plasmodium vivax
Evolutionary origin
Adaptation
Americas
Population genomics
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/s12936-022-04132-7
https://doaj.org/article/3259509fbbcf4821be1a6312e99e2156
Description
Summary:Abstract Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. Plasmodium vivax is the most prevalent human-infecting species in the Americas. However, the origins of this parasite in this continent are still debated. Similarly, it is now accepted that the existence of Plasmodium simium is explained by a P. vivax transfer from humans to monkey in America. However, many uncertainties still exist concerning the origin of the transfer and whether several transfers occurred. In this review, the most recent studies that addressed these questions using genetic and genomic approaches are presented.

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