Treatment of pemphigus vulgaris and pemphigus foliaceus: experience with 71 patients over a 20 year period Tratamento do pênfigo vulgar e pênfigo foliáceo: experiência com 71 pacientes no período de 20 anos
Forty one cases of pemphigus vulgaris and thirty cases of pemphigus foliaceus were investigated at Hospital Universitário Clementino Fraga Filho from 1978 to 1999. They were divided into two treatment groups: one group received up to 100 mg of oral prednisone daily and the other group received >1...
| Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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| Main Authors: | , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Universidade de São Paulo (USP)
2001
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| Subjects: | |
| Online Access: | https://doi.org/10.1590/S0036-46652001000100007 https://doaj.org/article/2cb22176825b4c5aa6742124c10d0998 |
| Summary: | Forty one cases of pemphigus vulgaris and thirty cases of pemphigus foliaceus were investigated at Hospital Universitário Clementino Fraga Filho from 1978 to 1999. They were divided into two treatment groups: one group received up to 100 mg of oral prednisone daily and the other group received >120 mg daily. The dose up to 100 mg provided good initial control of pemphigus vulgaris and pemphigus foliaceus and did not increase the mortality rate associated to disease. The dose >120 mg induced higher morbidity. These data allowed us to establish a regimen of oral prednisone (1-2 mg/kg/daily) with maximum of 120 mg daily in the treatment of pemphigus vulgaris and pemphigus foliaceus. Quarenta e um casos de pênfigo vulgar e trinta casos de pênfigo foliáceo foram investigados no Hospital Universitário Clementino Fraga Filho, no período 1978-1999. Os pacientes foram divididos em dois grupos de tratamento: um recebendo até 100 mg/dia de prednisona e o outro grupo >120 mg diariamente. Com o primeiro esquema, houve bom controle inicial dos pênfigos sem aumento da taxa de mortalidade associada às doenças. A dose acima de 120 mg induziu maior morbidade. Os resultados permitiram estabelecer um esquema de prednisona (1-2 mg/kg/dia) com dose máxima de 120 mg diários no tratamento dos pênfigos vulgar e foliáceo. |
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