Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study
Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant activity. Methods: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension (HTN group) that received a combination of...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:2ae181a349bf40f2aa06a9dc1e962208 2023-05-15T15:11:13+02:00 Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study Yori Yuliandra A. Armenia Helmi Arifin 2017-07-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2017.06.007 https://doaj.org/article/2ae181a349bf40f2aa06a9dc1e962208 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169117306184 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2017.06.007 https://doaj.org/article/2ae181a349bf40f2aa06a9dc1e962208 Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 7, Pp 614-618 (2017) Cassytha filiformis Blood pressure Oxidative stress Antioxidant activity Nitric oxide Correlation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2017.06.007 2022-12-31T01:28:20Z Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant activity. Methods: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension (HTN group) that received a combination of prednisone and salt for two weeks and oxidative stress-associated hypertension (HTN-OS group) that received additional induction of l-Nitro Arginine Methyl Esther (l-NAME) for two days. Each group was subdivided into 4 and treated intravenously with the extract 5; 10; and 20 mg/kg, and vehicle control. The systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded. The blood was taken before and at the end of recording for the measurement of serum concentration of nitric oxide (NO). The changes of blood pressure were analyzed by two-way ANOVA while its correlation with NO concentration was analyzed by Pearson's Correlation. Results: The study showed a significant antihypertensive effect of the extract as compared with control group (P < 0.05) in both hypertensive models. Extract in the dose of 5 mg/kg showed the best blood pressure lowering effect. However, the correlation analysis did not show an association between NO increase and blood pressure lowering effect (P > 0.05). Conclusions: The study concludes that C. filiformis extract in the dose of 5 mg/kg exhibits the best blood pressure lowering effect in both animal models. Antihypertensive activity of the extract is not correlated with its antioxidant effect. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Esther ENVELOPE(-57.700,-57.700,-61.917,-61.917) Asian Pacific Journal of Tropical Biomedicine 7 7 614 618 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cassytha filiformis Blood pressure Oxidative stress Antioxidant activity Nitric oxide Correlation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Cassytha filiformis Blood pressure Oxidative stress Antioxidant activity Nitric oxide Correlation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Yori Yuliandra A. Armenia Helmi Arifin Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study |
topic_facet |
Cassytha filiformis Blood pressure Oxidative stress Antioxidant activity Nitric oxide Correlation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant activity. Methods: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension (HTN group) that received a combination of prednisone and salt for two weeks and oxidative stress-associated hypertension (HTN-OS group) that received additional induction of l-Nitro Arginine Methyl Esther (l-NAME) for two days. Each group was subdivided into 4 and treated intravenously with the extract 5; 10; and 20 mg/kg, and vehicle control. The systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded. The blood was taken before and at the end of recording for the measurement of serum concentration of nitric oxide (NO). The changes of blood pressure were analyzed by two-way ANOVA while its correlation with NO concentration was analyzed by Pearson's Correlation. Results: The study showed a significant antihypertensive effect of the extract as compared with control group (P < 0.05) in both hypertensive models. Extract in the dose of 5 mg/kg showed the best blood pressure lowering effect. However, the correlation analysis did not show an association between NO increase and blood pressure lowering effect (P > 0.05). Conclusions: The study concludes that C. filiformis extract in the dose of 5 mg/kg exhibits the best blood pressure lowering effect in both animal models. Antihypertensive activity of the extract is not correlated with its antioxidant effect. |
format |
Article in Journal/Newspaper |
author |
Yori Yuliandra A. Armenia Helmi Arifin |
author_facet |
Yori Yuliandra A. Armenia Helmi Arifin |
author_sort |
Yori Yuliandra |
title |
Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study |
title_short |
Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study |
title_full |
Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study |
title_fullStr |
Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study |
title_full_unstemmed |
Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study |
title_sort |
antihypertensive and antioxidant activity of cassytha filiformis l.: a correlative study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2017.06.007 https://doaj.org/article/2ae181a349bf40f2aa06a9dc1e962208 |
long_lat |
ENVELOPE(-57.700,-57.700,-61.917,-61.917) |
geographic |
Arctic Esther |
geographic_facet |
Arctic Esther |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 7, Pp 614-618 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169117306184 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2017.06.007 https://doaj.org/article/2ae181a349bf40f2aa06a9dc1e962208 |
op_doi |
https://doi.org/10.1016/j.apjtb.2017.06.007 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
7 |
container_start_page |
614 |
op_container_end_page |
618 |
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1766342102740893696 |