Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Yori Yuliandra, A. Armenia, Helmi Arifin
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017
• Subjects: Cassytha filiformis; Blood pressure; Oxidative stress; Antioxidant activity; Nitric oxide; Correlation; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic; Esther
• Online Access: https://doi.org/10.1016/j.apjtb.2017.06.007; https://doaj.org/article/2ae181a349bf40f2aa06a9dc1e962208

Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant activity. Methods: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension (HTN group) that received a combination of prednisone and salt for two weeks and oxidative stress-associated hypertension (HTN-OS group) that received additional induction of l-Nitro Arginine Methyl Esther (l-NAME) for two days. Each group was subdivided into 4 and treated intravenously with the extract 5; 10; and 20 mg/kg, and vehicle control. The systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded. The blood was taken before and at the end of recording for the measurement of serum concentration of nitric oxide (NO). The changes of blood pressure were analyzed by two-way ANOVA while its correlation with NO concentration was analyzed by Pearson's Correlation. Results: The study showed a significant antihypertensive effect of the extract as compared with control group (P < 0.05) in both hypertensive models. Extract in the dose of 5 mg/kg showed the best blood pressure lowering effect. However, the correlation analysis did not show an association between NO increase and blood pressure lowering effect (P > 0.05). Conclusions: The study concludes that C. filiformis extract in the dose of 5 mg/kg exhibits the best blood pressure lowering effect in both animal models. Antihypertensive activity of the extract is not correlated with its antioxidant effect.