Crowberry inhibits cell proliferation and migration through a molecular mechanism that includes inhibition of DEK and Akt signaling in cholangiocarcinoma

Highlights 1. Crowberry alterd expression levels of key mediators in PI3K/Akt signaling pathway. 2. Crowberry alterd expression levels of key mediators in PI3K/Akt signaling pathway. 3. Crowberry suppressed the expression of the proto-oncogene DEK in vivo and in vitro. 4. Crowberry inhibited CCA pro...

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Bibliographic Details
Published in:Chinese Medicine
Main Authors: Xue Wang, Xuebing Zhou, Ludan Zhang, Xin Zhang, Chunyu Yang, Yingshi Piao, Jinhua Zhao, Lili Jin, Guihua Jin, Renbo An, Xiangshan Ren
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2022
Subjects:
Cholangiocarcinoma
Empetrum nigrum var. japonicum
Proliferation
Migration
DEK
Other systems of medicine
RZ201-999
Crowberry
Empetrum nigrum
Online Access:https://doi.org/10.1186/s13020-022-00623-6
https://doaj.org/article/26ca183c4d0148a2acc82091bb038319
Description
Summary:Highlights 1. Crowberry alterd expression levels of key mediators in PI3K/Akt signaling pathway. 2. Crowberry alterd expression levels of key mediators in PI3K/Akt signaling pathway. 3. Crowberry suppressed the expression of the proto-oncogene DEK in vivo and in vitro. 4. Crowberry inhibited CCA progression and migration through a molecular mechanism that includes inhibition of DEK and the Akt signaling pathway in vivo and in vitro.

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