Inmunohistochemical detection of pandemic SARSCoV- 2 antigens in lung tissue

The COVID-19 pandemic caused by the SARS-CoV-2 virus has generated globally more than 110.7 million infections and 2.4 million deaths. The severity of this infection can range from asymptomatic, mild to severe. To know the possible associations between the presence of the virus and histopathological...

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Bibliographic Details
Published in:Biomédica
Main Authors: Jorge Alonso Rivera, Sheryll Corchuelo, Edgar Alberto Parra, Eugenio Aladino Meek, Marcela Mercado, Orlando Torres-Fernández
Format: Article in Journal/Newspaper
Language:English
Spanish
Published: Instituto Nacional de Salud 2022
Subjects:
covid-19
lung
immunohistochemistry
antigens
viral
Medicine
R
Arctic medicine. Tropical medicine
RC955-962
Arctic
Online Access:https://doi.org/10.7705/biomedica.6132
https://doaj.org/article/263dc9970e29495fac9f12155f7065b9
Description
Summary:The COVID-19 pandemic caused by the SARS-CoV-2 virus has generated globally more than 110.7 million infections and 2.4 million deaths. The severity of this infection can range from asymptomatic, mild to severe. To know the possible associations between the presence of the virus and histopathological alterations found in tissues of fatal cases of COVID-19, the presence of the virus in the lung tissue of a patient with a clinical history of SARS-CoV-2 infection was evaluated. Lung tissue was histologically processed for immunohistochemical detection of SARSCoV-2. In the histopathological study, morphological changes associated with pneumonitis of viral origin were observed. Likewise, the location of the SARS-CoV-2 virus was observed mainly in the cytoplasm of the cells of the inflammatory infiltrate.

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