Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740

Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen an...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Yashu Chen, Mengyao Guo, Jifang Yang, Jigang Chen, Bijun Xie, Zhida Sun
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2019
Subjects:
isorenieratene
macular xanthophylls
TSPO
EPR
antioxidant and anti-UVB radiation
Biology (General)
QH301-705.5
Arctic
Arctic Ocean
Online Access:https://doi.org/10.3390/md17060316
https://doaj.org/article/23fe31531cdf4c43b9283c472f0e2df3
Description
Summary:Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen and hydroxyl radical in the UVB-induced auto-oxidation process using the EPR method. Within an ARPE-19 cell model damaged by UVB radiation, isorenieratene showed fine protective effects (1.13 ± 0.03 fold) compared with macular xanthophylls (MXs) through upregulating of tspo . The molecular docking was firstly performed to investigate the interaction of isorenieratene with TSPO as a special ligand. Results showed isorenieratene might form a better binding conformation (S-score −8.5438) than MXs and indicate that isorenieratene not only can function as a direct antioxidant but also activate tspo in ARPE-19 cells. Thus, isorenieratene might ease the UV-related damages including age-related macular degeneration (AMD).

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