CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens.
Chemokine receptor type 3 (CXCR3) plays an important role in CD8+ T cells migration during intracellular infections, such as Trypanosoma cruzi. In addition to chemotaxis, CXCR3 receptor has been described as important to the interaction between antigen-presenting cells and effector cells. We hypothe...
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ftdoajarticles:oai:doaj.org/article:23e3419d6736425f9d89132b616384fb 2023-05-15T15:07:41+02:00 CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. Camila Pontes Ferreira Leonardo Moro Cariste Isaú Henrique Noronha Danielle Fernandes Durso Joseli Lannes-Vieira Karina Ramalho Bortoluci Daniel Araki Ribeiro Douglas Golenbock Ricardo Tostes Gazzinelli José Ronnie Carvalho de Vasconcelos 2020-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008414 https://doaj.org/article/23e3419d6736425f9d89132b616384fb EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008414 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008414 https://doaj.org/article/23e3419d6736425f9d89132b616384fb PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008414 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008414 2022-12-31T07:16:57Z Chemokine receptor type 3 (CXCR3) plays an important role in CD8+ T cells migration during intracellular infections, such as Trypanosoma cruzi. In addition to chemotaxis, CXCR3 receptor has been described as important to the interaction between antigen-presenting cells and effector cells. We hypothesized that CXCR3 is fundamental to T. cruzi-specific CD8+ T cell activation, migration and effector function. Anti-CXCR3 neutralizing antibody administration to acutely T. cruzi-infected mice decreased the number of specific CD8+ T cells in the spleen, and those cells had impaired in activation and cytokine production but unaltered proliferative response. In addition, anti-CXCR3-treated mice showed decreased frequency of CD8+ T cells in the heart and numbers of plasmacytoid dendritic cells in spleen and lymph node. As CD8+ T cells interacted with plasmacytoid dendritic cells during infection by T. cruzi, we suggest that anti-CXCR3 treatment lowers the quantity of plasmacytoid dendritic cells, which may contribute to impair the prime of CD8+ T cells. Understanding which molecules and mechanisms guide CD8+ T cell activation and migration might be a key to vaccine development against Chagas disease as those cells play an important role in T. cruzi infection control. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 6 e0008414 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Camila Pontes Ferreira Leonardo Moro Cariste Isaú Henrique Noronha Danielle Fernandes Durso Joseli Lannes-Vieira Karina Ramalho Bortoluci Daniel Araki Ribeiro Douglas Golenbock Ricardo Tostes Gazzinelli José Ronnie Carvalho de Vasconcelos CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Chemokine receptor type 3 (CXCR3) plays an important role in CD8+ T cells migration during intracellular infections, such as Trypanosoma cruzi. In addition to chemotaxis, CXCR3 receptor has been described as important to the interaction between antigen-presenting cells and effector cells. We hypothesized that CXCR3 is fundamental to T. cruzi-specific CD8+ T cell activation, migration and effector function. Anti-CXCR3 neutralizing antibody administration to acutely T. cruzi-infected mice decreased the number of specific CD8+ T cells in the spleen, and those cells had impaired in activation and cytokine production but unaltered proliferative response. In addition, anti-CXCR3-treated mice showed decreased frequency of CD8+ T cells in the heart and numbers of plasmacytoid dendritic cells in spleen and lymph node. As CD8+ T cells interacted with plasmacytoid dendritic cells during infection by T. cruzi, we suggest that anti-CXCR3 treatment lowers the quantity of plasmacytoid dendritic cells, which may contribute to impair the prime of CD8+ T cells. Understanding which molecules and mechanisms guide CD8+ T cell activation and migration might be a key to vaccine development against Chagas disease as those cells play an important role in T. cruzi infection control. |
format |
Article in Journal/Newspaper |
author |
Camila Pontes Ferreira Leonardo Moro Cariste Isaú Henrique Noronha Danielle Fernandes Durso Joseli Lannes-Vieira Karina Ramalho Bortoluci Daniel Araki Ribeiro Douglas Golenbock Ricardo Tostes Gazzinelli José Ronnie Carvalho de Vasconcelos |
author_facet |
Camila Pontes Ferreira Leonardo Moro Cariste Isaú Henrique Noronha Danielle Fernandes Durso Joseli Lannes-Vieira Karina Ramalho Bortoluci Daniel Araki Ribeiro Douglas Golenbock Ricardo Tostes Gazzinelli José Ronnie Carvalho de Vasconcelos |
author_sort |
Camila Pontes Ferreira |
title |
CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. |
title_short |
CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. |
title_full |
CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. |
title_fullStr |
CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. |
title_full_unstemmed |
CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. |
title_sort |
cxcr3 chemokine receptor contributes to specific cd8+ t cell activation by pdc during infection with intracellular pathogens. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008414 https://doaj.org/article/23e3419d6736425f9d89132b616384fb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008414 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008414 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008414 https://doaj.org/article/23e3419d6736425f9d89132b616384fb |
op_doi |
https://doi.org/10.1371/journal.pntd.0008414 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
6 |
container_start_page |
e0008414 |
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1766339128919588864 |