Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008

Abstract Both diabetes mellitus (DM) and the metabolic syndrome (MetS) are associated with autonomic neuropathy, which predisposes to cardiac events and death. Measures of heart rate variability (HRV) can be used to monitor the activity of the autonomic nervous system (ANS), and there are strong ind...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Naomi Azulay, Roy Bjørkholt Olsen, Christopher Sivert Nielsen, Audun Stubhaug, Trond Geir Jenssen, Henrik Schirmer, Arnoldo Frigessi, Leiv Arne Rosseland, Christian Tronstad
Format: Article in Journal/Newspaper
Language:English
Published: Nature Portfolio 2022
Subjects:
Medicine
R
Science
Q
Tromsø
Online Access:https://doi.org/10.1038/s41598-022-15824-0
https://doaj.org/article/238c733401f34f30af76fb343d02fc59
Description
Summary:Abstract Both diabetes mellitus (DM) and the metabolic syndrome (MetS) are associated with autonomic neuropathy, which predisposes to cardiac events and death. Measures of heart rate variability (HRV) can be used to monitor the activity of the autonomic nervous system (ANS), and there are strong indications that HRV can be used to study the progression of ANS-related diabetes complications. This study aims to investigate differences in HRV in healthy, MetS and diabetic populations. Based on 7880 participants from the sixth health survey in Tromsø (Tromsø 6, 2007–2008), we found a significant negative association between the number of MetS components and HRV as estimated from short-term pulse wave signals (PRV). This decrease in PRV did not appear to be linear, instead it leveled off after the third component, with no significant difference in PRV between the MetS and DM populations. There was a significant negative association between HbA1c and PRV, showing a decrease in PRV occurring already within the normal HbA1c range. The MetS and DM populations are different from healthy controls with respect to PRV, indicating impaired ANS in both conditions. In the future, a study with assessment of PRV measurements in relation to prospective cardiovascular events seems justified.

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