Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe.

Alveolar echinococcosis (AE) is a severe helminth disease affecting humans, which is caused by the fox tapeworm Echinococcus multilocularis. AE represents a serious public health issue in larger regions of China, Siberia, and other regions in Asia. In Europe, a significant increase in prevalence sin...

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Bibliographic Details
Published in:PLoS Neglected Tropical Diseases
Main Authors: Jenny Knapp, Jean-Mathieu Bart, Patrick Giraudoux, Marie-Louise Glowatzki, Isabelle Breyer, Francis Raoul, Peter Deplazes, Georg Duscher, Karel Martinek, Pavol Dubinsky, Marie-Hélène Guislain, Florence Cliquet, Thomas Romig, Andrzej Malczewski, Bruno Gottstein, Renaud Piarroux
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science (PLoS) 2009
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Arctic
Jura
Siberia
Online Access:https://doi.org/10.1371/journal.pntd.0000452
https://doaj.org/article/22ed9d55b1624116bbce05258f74e8d4
Description
Summary:Alveolar echinococcosis (AE) is a severe helminth disease affecting humans, which is caused by the fox tapeworm Echinococcus multilocularis. AE represents a serious public health issue in larger regions of China, Siberia, and other regions in Asia. In Europe, a significant increase in prevalence since the 1990s is not only affecting the historically documented endemic area north of the Alps but more recently also neighbouring regions previously not known to be endemic. The genetic diversity of the parasite population and respective distribution in Europe have now been investigated in view of generating a fine-tuned map of parasite variants occurring in Europe. This approach may serve as a model to study the parasite at a worldwide level.The genetic diversity of E. multilocularis was assessed based upon the tandemly repeated microsatellite marker EmsB in association with matching fox host geographical positions. Our study demonstrated a higher genetic diversity in the endemic areas north of the Alps when compared to other areas.The study of the spatial distribution of E. multilocularis in Europe, based on 32 genetic clusters, suggests that Europe can be considered as a unique global focus of E. multilocularis, which can be schematically drawn as a central core located in Switzerland and Jura Swabe flanked by neighbouring regions where the parasite exhibits a lower genetic diversity. The transmission of the parasite into peripheral regions is governed by a "mainland-island" system. Moreover, the presence of similar genetic profiles in both zones indicated a founder event.

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