Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

• Published in: Marine Drugs
• Main Authors: Santana A.L. Thomas, Anthony Sanchez, Younghoon Kee, Nerida G. Wilson, Bill J. Baker
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI AG 2019
• Subjects: briarane diterpene; cytotoxicity screening; deep sea; pennatulacea; marine natural products; Biology (General); QH301-705.5; Antarctic; Austral; Antarc*
• Online Access: https://doi.org/10.3390/md17090513; https://doaj.org/article/1e0cf715bf5e474095001ad96870103e

An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C ( 1 − 3 ) along with a trinorditerpene, enbepeanone A ( 4 ), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.