Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C ( 1 − 3 ) along with a trinorditerpene, enbepeanone A ( 4 ), which bears a new carbon skeleton. Structure elu...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Santana A.L. Thomas, Anthony Sanchez, Younghoon Kee, Nerida G. Wilson, Bill J. Baker
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2019
Subjects:
briarane diterpene
cytotoxicity screening
deep sea
pennatulacea
marine natural products
Biology (General)
QH301-705.5
Antarctic
Austral
Antarc*
Online Access:https://doi.org/10.3390/md17090513
https://doaj.org/article/1e0cf715bf5e474095001ad96870103e
Description
Summary:An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C ( 1 − 3 ) along with a trinorditerpene, enbepeanone A ( 4 ), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

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