Is autonomic function associated with left ventricular systolic function in Chagas heart disease patients undergoing treatment for heart failure?

Introduction The association between cardiac autonomic and left ventricular (LV) dysfunction in Chagas disease (ChD) is controversial. Methods A standardized protocol that includes the Valsalva maneuver, a respiratory sinus arrhythmia (RSA) test, and an echocardiographic examination was used. Spearm...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical
Main Authors: Lotte Raadschilders, Manoel Otavio da Costa Rocha, Lidiane Sousa, Jan Nouwen, Antonio Luiz Ribeiro
Format: Article in Journal/Newspaper
Language:English
Spanish
Portuguese
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2014
Subjects:
Chagas disease
Autonomic function
Valsalva index
Arctic medicine. Tropical medicine
RC955-962
Arctic
Rho
Online Access:https://doi.org/10.1590/0037-8682-0013-2013
https://doaj.org/article/1dae63b38c9b4f008548dda89b1d53ec
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Summary:Introduction The association between cardiac autonomic and left ventricular (LV) dysfunction in Chagas disease (ChD) is controversial. Methods A standardized protocol that includes the Valsalva maneuver, a respiratory sinus arrhythmia (RSA) test, and an echocardiographic examination was used. Spearman correlation coefficients (rho) were used to investigate associations. Results The study population consisted of 118 ChD patients undergoing current medical treatment, with an average LV ejection fraction of 51.4±2.6%. The LV ejection fraction and diastolic dimension were correlated with the Valsalva index (rho=0.358, p<0.001 and rho=-0.266, p=0.004, respectively) and the RSA (rho=0.391, p<0.001 and rho=-0.311, p<0.001, respectively). Conclusions The impairment of LV function is directly associated with a reduction of cardiac autonomic modulation in ChD.

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