In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence

Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed...

Full description

Bibliographic Details
Main Authors: Carla M. S. MENEZES, Karin KIRCHGATTER, Sílvia M. F. DI SANTI, Carine SAVALLI, Fabíola G. MONTEIRO, Gilberto A. PAULA, Elizabeth I. FERREIRA
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP) 1999
Subjects:
Erythromycin
Modulating effect
Antimalarial activity
Chloroquine P. falciparum resistance
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doaj.org/article/1ad213c5f16242ee891a405642311ff5
Description
Summary:Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate.

Similar Items