Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway
Objective: To study the effect of fructose 1,6-diphosphate (FDP) on myocardial ischemia reperfusion injury in rats and its molecular mechanism. Methods: Male SPF SD rats were selected as experimental animals and randomly divided into four groups. Sham group received sham operation, I/R group were ma...
Published in: | Asian Pacific Journal of Tropical Medicine |
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ftdoajarticles:oai:doaj.org/article:19fcc536d6244fa59049f06c694393b9 2023-05-15T15:12:16+02:00 Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway Ju-Fei Wang Cheng Jiang 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.225023 https://doaj.org/article/19fcc536d6244fa59049f06c694393b9 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=2;spage=147;epage=150;aulast=Wang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.225023 https://doaj.org/article/19fcc536d6244fa59049f06c694393b9 Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 2, Pp 147-150 (2018) fructose 1 6-diphosphate myocardial ischemia reperfusion apoptosis janus kinase 2 signal transducer activator of transcription 3 Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.225023 2022-12-31T13:11:13Z Objective: To study the effect of fructose 1,6-diphosphate (FDP) on myocardial ischemia reperfusion injury in rats and its molecular mechanism. Methods: Male SPF SD rats were selected as experimental animals and randomly divided into four groups. Sham group received sham operation, I/R group were made into myocardial ischemia reperfusion injury models, FDP group were made into myocardial ischemia reperfusion injury models and then were given FDP intervention, and FDP+AG490 group were made into myocardial ischemia reperfusion injury models and then were given FDP and JAK2 inhibitor AG490 intervention. Results: CK, CK-MB, cTnI and LDH contents in serum as well as Bax and Caspase-3 protein expression in myocardial tissue of I/R group were significantly higher than those of Sham group whereas Bcl-2, p-JAK2 and p-STAT3 protein expression in myocardial tissues were significantly lower than those of Sham group; CK, CK-MB, cTnI and LDH contents in serum as well as Bax and Caspase-3 protein expression in myocardial tissue of FDP group were significantly lower than those of I/R group whereas Bcl-2, p-JAK2 and p-STAT3 protein expression in myocardial tissue were significantly higher than those of I/R group; CK, CK-MB, cTnI and LDH contents in serum as well as Bax and Caspase-3 protein expression in myocardial tissue of FDP+AG490 group were significantly higher than those of FDP group whereas Bcl-2 protein expression in myocardial tissue was significantly lower than that of FDP group. Conclusion: FDP could reduce the myocardial ischemia reperfusion injury in rats by activating the JAK2/STAT3 pathway. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Janus ENVELOPE(163.100,163.100,-71.067,-71.067) Asian Pacific Journal of Tropical Medicine 11 2 147 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
fructose 1 6-diphosphate myocardial ischemia reperfusion apoptosis janus kinase 2 signal transducer activator of transcription 3 Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
fructose 1 6-diphosphate myocardial ischemia reperfusion apoptosis janus kinase 2 signal transducer activator of transcription 3 Arctic medicine. Tropical medicine RC955-962 Ju-Fei Wang Cheng Jiang Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway |
topic_facet |
fructose 1 6-diphosphate myocardial ischemia reperfusion apoptosis janus kinase 2 signal transducer activator of transcription 3 Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To study the effect of fructose 1,6-diphosphate (FDP) on myocardial ischemia reperfusion injury in rats and its molecular mechanism. Methods: Male SPF SD rats were selected as experimental animals and randomly divided into four groups. Sham group received sham operation, I/R group were made into myocardial ischemia reperfusion injury models, FDP group were made into myocardial ischemia reperfusion injury models and then were given FDP intervention, and FDP+AG490 group were made into myocardial ischemia reperfusion injury models and then were given FDP and JAK2 inhibitor AG490 intervention. Results: CK, CK-MB, cTnI and LDH contents in serum as well as Bax and Caspase-3 protein expression in myocardial tissue of I/R group were significantly higher than those of Sham group whereas Bcl-2, p-JAK2 and p-STAT3 protein expression in myocardial tissues were significantly lower than those of Sham group; CK, CK-MB, cTnI and LDH contents in serum as well as Bax and Caspase-3 protein expression in myocardial tissue of FDP group were significantly lower than those of I/R group whereas Bcl-2, p-JAK2 and p-STAT3 protein expression in myocardial tissue were significantly higher than those of I/R group; CK, CK-MB, cTnI and LDH contents in serum as well as Bax and Caspase-3 protein expression in myocardial tissue of FDP+AG490 group were significantly higher than those of FDP group whereas Bcl-2 protein expression in myocardial tissue was significantly lower than that of FDP group. Conclusion: FDP could reduce the myocardial ischemia reperfusion injury in rats by activating the JAK2/STAT3 pathway. |
format |
Article in Journal/Newspaper |
author |
Ju-Fei Wang Cheng Jiang |
author_facet |
Ju-Fei Wang Cheng Jiang |
author_sort |
Ju-Fei Wang |
title |
Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway |
title_short |
Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway |
title_full |
Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway |
title_fullStr |
Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway |
title_full_unstemmed |
Fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through JAK2/STAT3 pathway |
title_sort |
fructose 1,6-diphosphate alleviates myocardial ischemia reperfusion injury in rats through jak2/stat3 pathway |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.225023 https://doaj.org/article/19fcc536d6244fa59049f06c694393b9 |
long_lat |
ENVELOPE(163.100,163.100,-71.067,-71.067) |
geographic |
Arctic Janus |
geographic_facet |
Arctic Janus |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 2, Pp 147-150 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=2;spage=147;epage=150;aulast=Wang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.225023 https://doaj.org/article/19fcc536d6244fa59049f06c694393b9 |
op_doi |
https://doi.org/10.4103/1995-7645.225023 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
2 |
container_start_page |
147 |
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1766342980560486400 |