Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities

• Main Authors: Benedito Barraviera, Paulo Câmara Marques Pereira, Jussara Marcondes Machado, Maria Julia de Souza, Carlos Roberto G. Lima, Paulo Roberto Curi, Rinaldo Poncio Mendes, Domingos Alves Meira
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1991
• Subjects: Fenótipo acetilador da isoniazida; Paracoccidioidomicose; Glicose-6-fosfato desidrogenase (G6PD); Glutationa redutase; Sulfadoxina; Isoniazid acetylating phenotype; Paracoccidioidomycosis; Glucose-6-phosphate dehydrogenase (G6PD); Glutathione reductase; Sulfadoxin; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doaj.org/article/13cca45706f0473798d9eaed2c7fc0e4

The authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase and glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males and 6 females) aged 17 to 58 years. Twenty one (53.84%) of the patients presented a slow acetylatingphenotype and 18(46.16%) a fast acetylating phenotype. Glucose-6-phosphate- dehydrogenase (G6PD) acti vity was decreased in 5(23.80%) slow acetylators and in 4(22.22%) fast acetylators. Glutathione reductase activity was decreased in 14 (66.66%) slow acetylators and in 12 (66.66%) fast acetylators. Serum levels of free and total sulfadoxin Were higher in slow acetylator (p < 0.02). Analysis of the resultspermitted us to conclude that serum sulfadoxin levels are related to the acetylatorphenotype. Furthermore, sulfadoxin levels were always above 50 µg/ml, a value considered therapeutic. Glutathione reductase deficiency observed in 66% of patients may be related to the intestinal malabsorption of nutrients, among them riboflavin, a FAD precursor vitamin, inpatients with paracoceidioidomycosis. Os autores avaliaram o fenótipo acetilador da isoniazida, hematócrito, hemoglobina, atividade da glicose-6- fosfato desidrogenase, glutationa redutase e os níveis séricos de sulfadoxina de 39 doentes com paracoccidíoidomicose, senão 33 do sexo masculino e 6 do feminino, com idades compreendidas entre 17 e 58 anos. Vinte e um (53,84%) doentes apresentaram fenótipo acetilador lento e 18 (46,16%) rápido. A atividade da glicose-6-fosfato desidrogenase (G6PD) esteve diminuída em 5 (23,80%) acetiladores lentos e 4 (22,22%) rápidos. A atividade da glutationa redutase esteve diminuída em 14 (66,66%) acetiladores lentos e 12 (66,66%) rápidos. Os níveis séricos de sulfadoxina livre e total foram maiores nos acetiladores lentos (p < 0,02). A análise dos resultados permite concluir que os níveis séricos de sulfadoxina relaciona-se com o fenótipo acetilador. Além disso, os níveis estiveram ...