Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

• Published in: Frontiers in Marine Science
• Main Authors: Vedanjali Gogineni, Joonseok Oh, Amanda L. Waters, Michelle Kelly, Robert Stone, Mark T. Hamann
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media S.A. 2020
• Subjects: marine natural products; sponges; guanidine alkaloids; monanchocidin A; anticancer; Science; Q; General. Including nature conservation; geographical distribution; QH1-199.5; Subarctic
• Online Access: https://doi.org/10.3389/fmars.2020.00058; https://doaj.org/article/0e3da6e07d784cc8ae9d912b07f2c3a2

Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of MonanchoraCarter, 1883 and a specimen closely comparable to Monanchora pulchra (Lambe, 1894/1895) (Class Demospongiae, Order Poecilosclerida, Family Crambeidae), yielded a known compound, monanchocidin A. Monanchocidin A, a secondary metabolite, showed very modest antibacterial, antifungal, and antiprotozoal activities with IC50 values ranging between 255.75 and 7288.92 μM. Monanchocidin A also exhibited potent selective activity for the melanoma panel in the NCI cancer cell screening panel.