Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of MonanchoraCarter, 1883 and a specimen closely comparable to Monanchora pulchra (Lambe, 1894/1895) (Class Demospong...

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Bibliographic Details
Published in:Frontiers in Marine Science
Main Authors: Vedanjali Gogineni, Joonseok Oh, Amanda L. Waters, Michelle Kelly, Robert Stone, Mark T. Hamann
Format: Article in Journal/Newspaper
Language:English
Published: Frontiers Media S.A. 2020
Subjects:
marine natural products
sponges
guanidine alkaloids
monanchocidin A
anticancer
Science
Q
General. Including nature conservation
geographical distribution
QH1-199.5
Subarctic
Online Access:https://doi.org/10.3389/fmars.2020.00058
https://doaj.org/article/0e3da6e07d784cc8ae9d912b07f2c3a2
Description
Summary:Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of MonanchoraCarter, 1883 and a specimen closely comparable to Monanchora pulchra (Lambe, 1894/1895) (Class Demospongiae, Order Poecilosclerida, Family Crambeidae), yielded a known compound, monanchocidin A. Monanchocidin A, a secondary metabolite, showed very modest antibacterial, antifungal, and antiprotozoal activities with IC50 values ranging between 255.75 and 7288.92 μM. Monanchocidin A also exhibited potent selective activity for the melanoma panel in the NCI cancer cell screening panel.

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