Omega-3 polyunsaturated fatty acid profiles and relationship with cardiometabolic risk factors in Cree (Eeyouch) of Northern Québec

• Published in: International Journal of Circumpolar Health
• Main Authors: Françoise Proust, Olivia Drescher, Elhadji A. Laouan-Sidi, Elizabeth Robinson, Michel Lucas, Éric Dewailly
• Format: Article in Journal/Newspaper
• Language: English
• Published: Taylor & Francis Group 2016
• Subjects: polyunsaturated fatty acids; traditional food; fish; nutritional transition; James Bay Cree; cardiovascular disease risk factors; lipids; blood glucose; Arctic medicine. Tropical medicine; RC955-962; Arctic; Canada; Circumpolar Health; International Journal of Circumpolar Health; James Bay
• Online Access: https://doi.org/10.3402/ijch.v75.30361; https://doaj.org/article/0bde928c55f840ebbcc5bfda72771869

Background: n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) from fish are known modulators of cardiometabolic risk factors. Objective: To examine fatty acids (FAs) status and the relationship between n-3 LC-PUFA and cardiometabolic risk factors in Cree participants. Design: We analyzed data from a cross-sectional study (n=829) conducted in Cree adults (aged 18–74 years) from 7 communities of the James Bay territory of Quebec (Canada) in 2005–2009. Sociodemographic, lifestyle, clinical and anthropometric data were collected. FAs were quantified in red blood cells (RBCs) under fasting conditions. Results: A total of 89% of the participants were overweight (with 69% obesity), 33% had hypertriglyceridemia, 44% had low plasma HDL-c and 77% had fasting plasma insulin ≥90 pmol/l. Total n-3 PUFAs accounted for 6% of total FAs and were higher among older participants, while n-6 PUFAs accounted for 31% of total FAs and were higher among younger participants. According to the adjusted multiple linear regression models, n-3 LC-PUFA was associated (p<0.05) with higher total cholesterol, LDL-c and apo B-100, and was also associated (p<0.05) with lower blood glucose. Conclusion: Overall, this study showed that n-3 LC-PUFA levels measured in the RBCs of the Cree adults are relatively low and tend towards lower levels among youth. These levels might be insufficient to offset the prevalence of cardiometabolic risk factors.