Improvement of Antarctic krill oil on reserpine induced zebrafish depression model

• Main Authors: GUO Meng-jie, LIU Yun, WU Zhi-qiang, JIANG Guo-liang
• Format: Article in Journal/Newspaper
• Language: English; Chinese
• Published: ZHU Beiwei 2023
• Subjects: antarctic krill oil; reserpine; zebrafish; depression model; neuroinflammation; Food processing and manufacture; TP368-456; Antarc*; Antarctic; Antarctic Krill
• Online Access: https://doi.org/10.13652/j.spjx.1003.5788.2022.81050; https://doaj.org/article/07b9af16a9ba4065abb160e321e6968c

Objective: This study aimed to investigate the effect of Antarctic krill oil on zebrafish model of depression. Methods: The zebrafish ( Danio rerio ) model of depression was induced by 40 mg/L reserpine, and five groups, i.e., blank control group, model group, fluoxetine group, low-dose krill oil group and high-dose krill oil group were investigated and compared, buy using new tank test (NTT) and light dark box test (LDB). The central nervous system serotonin (5-HT), dopamine (DA), monoamine oxidase A (MAO-A) Interleukin-6 (IL-6), tumor necrosis factor α (TNF- α ) and systemic cortisol (COR) levels of the five groups were analyzed. Results: Reserpine 40 mg/L caused depressive behavior in zebrafish, while the addition of prawn oil reduced the this behavior, by increasing the levels of monoamine neurotransmitters including 5-HT and DA in the brain and decreasing the levels of MAO-A, IL-6 and TNF- α proinflammatory factors and systemic COR levels. Conclusion: Antarctic krill oil can improve the depression of zebrafish by reducing neuroinflammation and regulating neuroendocrine.