Improvement of Antarctic krill oil on reserpine induced zebrafish depression model
Objective: This study aimed to investigate the effect of Antarctic krill oil on zebrafish model of depression. Methods: The zebrafish ( Danio rerio ) model of depression was induced by 40 mg/L reserpine, and five groups, i.e., blank control group, model group, fluoxetine group, low-dose krill oil gr...
Main Authors: | , , , |
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Format: | Article in Journal/Newspaper |
Language: | English Chinese |
Published: |
ZHU Beiwei
2023
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Subjects: | |
Online Access: | https://doi.org/10.13652/j.spjx.1003.5788.2022.81050 https://doaj.org/article/07b9af16a9ba4065abb160e321e6968c |
Summary: | Objective: This study aimed to investigate the effect of Antarctic krill oil on zebrafish model of depression. Methods: The zebrafish ( Danio rerio ) model of depression was induced by 40 mg/L reserpine, and five groups, i.e., blank control group, model group, fluoxetine group, low-dose krill oil group and high-dose krill oil group were investigated and compared, buy using new tank test (NTT) and light dark box test (LDB). The central nervous system serotonin (5-HT), dopamine (DA), monoamine oxidase A (MAO-A) Interleukin-6 (IL-6), tumor necrosis factor α (TNF- α ) and systemic cortisol (COR) levels of the five groups were analyzed. Results: Reserpine 40 mg/L caused depressive behavior in zebrafish, while the addition of prawn oil reduced the this behavior, by increasing the levels of monoamine neurotransmitters including 5-HT and DA in the brain and decreasing the levels of MAO-A, IL-6 and TNF- α proinflammatory factors and systemic COR levels. Conclusion: Antarctic krill oil can improve the depression of zebrafish by reducing neuroinflammation and regulating neuroendocrine. |
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