EFFECT OF BACILLUS OF CALMETTE-GUÉRIN, AVRIDINE AND Propionibacterium acnes AS IMMUNOMODULATORS ON RABIES IN MICE

The cellular and humoral immune responses of mice inoculated with rabies virus and treated with the Bacillus of Calmette-Guérin, Avridine and Propionibacterium acnes were evaluated in this paper. There was a higher percentage of surviving mice in groups submitted to P. acnes treatment. Lower levels...

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Bibliographic Details
Main Authors: MEGID J., PERAÇOLI M.T.S., CURI P.R., ZANETTI C.R., CABRERA W.H., VASSAO R., ITO F.H.
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP) 1999
Subjects:
Rabies
Immunomodulators
Cellular immunity
Humoral immunity
g -interferon
Mice
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Calmette
Online Access:https://doaj.org/article/0614f2c0aa1a4a129094744616d46080
Description
Summary:The cellular and humoral immune responses of mice inoculated with rabies virus and treated with the Bacillus of Calmette-Guérin, Avridine and Propionibacterium acnes were evaluated in this paper. There was a higher percentage of surviving mice in groups submitted to P. acnes treatment. Lower levels of interferon- g (IFN- g ) were found in infected mice. The intra-pad inoculation test (IPI) was not effective to detect cellular immune response, contrary to the results found in MIF reaction. The survival of mice did not present correlation with the levels of antirabies serum neutralizing (SN) antibodies titers, IFN- g concentration and MIF response.

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