Mutations in Influenza A Virus (H5N1) and Possible Limited Spread, Turkey, 2006

We report mutations in influenza A virus (H5N1) strains associated with 2 outbreaks in Turkey. Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died.

Bibliographic Details
Published in:Emerging Infectious Diseases
Main Authors: Ender Altiok, Fulya Taylan, Osman Ş. Yenen, Gülşah Demirkeser, Mürvet Bozaci, Derya Önel, Birsen Akcadag, A. Selma Iyisan, Meral Ciblak, Emel Bozkaya, Sirin Yuksel, Selim Badur
Format: Article in Journal/Newspaper
Language:English
Published: Centers for Disease Control and Prevention 2008
Subjects:
Avian flu pandemic
H5N1
pandemic
mutation
outbreak
Turkey
Medicine
R
Infectious and parasitic diseases
RC109-216
Avian flu
Online Access:https://doi.org/10.3201/eid1403.061237
https://doaj.org/article/057f5fe31e754786a3477ebba558af52
Description
Summary:We report mutations in influenza A virus (H5N1) strains associated with 2 outbreaks in Turkey. Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died.

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