Efficient, parallel synthesis of Strecker’s α-aminonitriles catalyzed by in-situ generated carbonic acid

• Published in: Results in Chemistry
• Main Authors: Swati Jaydeokar, Priyanka Bandivadekar, Vijay Chavan, Ganesh Chaturbhuj
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2024
• Subjects: Strecker synthesis; Amino nitriles; Trimethylsilyl cyanide; Carbonic acid; Chemistry; QD1-999
• Online Access: https://doi.org/10.1016/j.rechem.2024.101561; https://doaj.org/article/04edc4bae66043739945f44a76d99e0c

A parallel, rapid, efficient, one-pot and three-component synthesis of α-aminonitriles designed for the Strecker reaction starting from the corresponding carbonyl compounds, amines, and trimethylsilyl cyanide catalyzed by carbonic acid produced in-situ from dry ice has been devised. Carbonic acid is a non-toxic and eco-friendly catalyst. Carbonic acid is readily accessible and does not leave any residual traces. The main advantages of the current method include high yields, a reduced reaction time, an easy experimental method, a simple workup procedure, and the suitability of the catalyst to withstand a wide range of substrate scopes. Various aldehydes and aliphatic ketone reacted well with aromatic amines to give Strecker product in a shorter reaction time in the presence of carbonic acid as a green catalyst. This provides economic and environmental benefits.