Efficient, parallel synthesis of Strecker’s α-aminonitriles catalyzed by in-situ generated carbonic acid
A parallel, rapid, efficient, one-pot and three-component synthesis of α-aminonitriles designed for the Strecker reaction starting from the corresponding carbonyl compounds, amines, and trimethylsilyl cyanide catalyzed by carbonic acid produced in-situ from dry ice has been devised. Carbonic acid is...
| Published in: | Results in Chemistry |
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| Main Authors: | , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Elsevier
2024
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| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.rechem.2024.101561 https://doaj.org/article/04edc4bae66043739945f44a76d99e0c |
| Summary: | A parallel, rapid, efficient, one-pot and three-component synthesis of α-aminonitriles designed for the Strecker reaction starting from the corresponding carbonyl compounds, amines, and trimethylsilyl cyanide catalyzed by carbonic acid produced in-situ from dry ice has been devised. Carbonic acid is a non-toxic and eco-friendly catalyst. Carbonic acid is readily accessible and does not leave any residual traces. The main advantages of the current method include high yields, a reduced reaction time, an easy experimental method, a simple workup procedure, and the suitability of the catalyst to withstand a wide range of substrate scopes. Various aldehydes and aliphatic ketone reacted well with aromatic amines to give Strecker product in a shorter reaction time in the presence of carbonic acid as a green catalyst. This provides economic and environmental benefits. |
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