Commercial Vaccines Do Not Confer Protection against Two Genogroups of Piscirickettsia salmonis , LF-89 and EM-90, in Atlantic Salmon

In Atlantic salmon, vaccines have failed to control and prevent Piscirickettsiosis , for reasons that remain elusive. In this study, we report the efficacy of two commercial vaccines developed with the Piscirickettsia salmonis isolates AL100005 and AL 20542 against another two genogroups which are c...

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Bibliographic Details
Published in:Biology
Main Authors: Carolina Figueroa, Débora Torrealba, Byron Morales-Lange, Luis Mercado, Brian Dixon, Pablo Conejeros, Gabriela Silva, Carlos Soto, José A. Gallardo
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2022
Subjects:
pentavalent vaccine
bacterin vaccine
live attenuated vaccine
monovalent vaccine
Piscirickettsiosis
Salmo salar
Biology (General)
QH301-705.5
Atlantic salmon
Online Access:https://doi.org/10.3390/biology11070993
https://doaj.org/article/01ba0e2d3669463dac2b14913a393fda
Description
Summary:In Atlantic salmon, vaccines have failed to control and prevent Piscirickettsiosis , for reasons that remain elusive. In this study, we report the efficacy of two commercial vaccines developed with the Piscirickettsia salmonis isolates AL100005 and AL 20542 against another two genogroups which are considered highly and ubiquitously prevalent in Chile: LF-89 and EM-90. Two cohabitation trials were performed to mimic field conditions and vaccine performance: (1) post-smolt fish were challenged with a single infection of LF-89, (2) adults were coinfected with EM-90, and a low level coinfection of sea lice. In the first trial, the vaccine delayed smolt mortalities by two days; however, unvaccinated and vaccinated fish did not show significant differences in survival (unvaccinated: 60.3%, vaccinated: 56.7%; p = 0.28). In the second trial, mortality started three days later for vaccinated fish than unvaccinated fish. However, unvaccinated and vaccinated fish did not show significant differences in survival (unvaccinated: 64.6%, vaccinated: 60.2%, p = 0.58). Thus, we found no evidence that the evaluated vaccines confer effective protection against the genogroups LF-89 and EM-90 of P. salmonis with estimated relative survival proportions (RPSs) of −9% and −12%, respectively. More studies are necessary to evaluate whether pathogen heterogeneity is a key determinant of the lack of vaccine efficacy against P. salmonis .

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