FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE

Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishm...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo
Main Authors: Cláudia Maria Valete-Rosalino, Maria Helena Araujo-Melo, Débora Cristina de Oliveira Bezerra, Renata Oliveira de Barcelos, Vanessa de Melo-Ferreira, Tânia Salgado de Sousa Torraca, Ana Cristina da Costa Martins, João Soares Moreira, Mirian Catherine Melgares Vargas, Frederico Pereira Bom Braga, Mariza de Matos Salgueiro, Maurício Naoto Saheki, Armando Oliveira Schubach
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP) 2014
Subjects:
Mucocutaneous Leishmaniasis
Drug Toxicity
Meglumine antimoniate
Hearing loss
Tinnitus
Dizziness
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1590/S0036-46652014000500012
https://doaj.org/article/01ac345408fb4ed6a41bdaccd7d6bdb9
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Summary:Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.

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