Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using $Pd^{0}‐CalB$ CLEA as a Biohybrid Catalyst

Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipaseB of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DK...

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Bibliographic Details
Published in:Chemistry – A European Journal
Main Authors: Gustafson, Karl P. J., Görbe, Tamás, deGonzalo‐Calvo, Gonzalo, Yuan, Ning, Schreiber, Cynthia L., Shchukarev, Andrey, Tai, Cheuk‐Wai, Persson, Ingmar, Zou, Xiaodong, Bäckvall, Jan‐E.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley-VCH 2019
Subjects:
info:eu-repo/classification/ddc/540
Antarc*
Antarctica
Online Access:https://bib-pubdb1.desy.de/record/426151
https://bib-pubdb1.desy.de/search?p=id:%22PUBDB-2019-03624%22
Description
Summary:Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipaseB of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.

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