UPTAKE, TISSUE DISTRIBUTION AND METABOLISM OF C-14-LABELED TRIBUTYLTIN (TBT) IN THE DOG-WHELK, NUCELLA-LAPILLUS

A study of tributyltin (TBT) uptake, tissue distribution and breakdown in dog-whelks, Nucella lapillus, was carried out using 14C-labelled tributyltin chloride. The compound was introduced into animals by exposure to sea-water, from a diet of labelled mussels and by injection. Measurements of 14C we...

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Bibliographic Details
Main Authors: GW BRYAN, DA BRIGHT, LG HUMMERSTONE, GR BURT
Format: Article in Journal/Newspaper
Language:unknown
Published: 1993
Subjects:
Ecology not elsewhere classified
Plant biology not elsewhere classified
Zoology not elsewhere classified
Science & Technology
Life Sciences & Biomedicine
Marine & Freshwater Biology
TRI-N-BUTYLTIN
ANTIFOULING PAINTS
IMPOSEX
CHLORIDE
ACCUMULATION
CONTAMINATION
EXPOSURE
SYSTEM
CRABS
FISH
Dog whelk
Nucella lapillus
Online Access:http://hdl.handle.net/10779/DRO/DU:23210138.v2
https://figshare.com/articles/journal_contribution/UPTAKE_TISSUE_DISTRIBUTION_AND_METABOLISM_OF_C-14-LABELED_TRIBUTYLTIN_TBT_IN_THE_DOG-WHELK_NUCELLA-LAPILLUS/23210138
Description
Summary:A study of tributyltin (TBT) uptake, tissue distribution and breakdown in dog-whelks, Nucella lapillus, was carried out using 14C-labelled tributyltin chloride. The compound was introduced into animals by exposure to sea-water, from a diet of labelled mussels and by injection. Measurements of 14C were made on tissue extracts containing total 14C, TBT+DBT and TBT. Organs examined included digestive gland, kidney, mantle, foot, viscera, gonads and blood. Absorption of dissolved TBT occurred primarily via tissues associated with the mantle: autoradiographic evidence showed that of these the ctenidium (gill) and osphradium were probably most important. Of non-reproductive tissues, mantle displayed least evidence of TBT degradation whereas kidney and digestive gland contained lower proportions of 14C as TBT (~60%) than other tissues. By virtue of its more rapid response, initially at least, the kidney had a primary role in degrading dissolved TBT that reached the blood. Dog-whelks feeding on labelled Mytilus edulis absorbed organotins very efficiently via the digestive gland, which then played a major role in TBT breakdown. However, the capacity for degradation is not sufficient to prevent, TBT concentration factors of the order of 100,000 (dry tissue/water) being attained in N. lapillus. Autoradiography revealed surprisingly high grain-counts in nerves, which may be significant in view of evidence in the literature that neurohormones are intermediaries in the chain linking TBT with imposex.

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