Border Collie array data for 58 dogs from Illumina 170k CanineHD BeadChip ... : Arginine to glutamine mutation in olfactomedin-like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed. ...

• Main Authors: Summers, Kim, Pugh, Carys, Carlisle, Ailsa
• Format: Dataset
• Language: English
• Published: The Roslin Institute. University of Edinburgh. School of Veterinary Studies 2018
• Subjects: Glaucoma; Goniodysgenesis; Canine; Dog; Eye; OLFML3; Border Collie; SNP; GWAS; Veterinary Sciences Agriculture and related subjects; Canis lupus
• Online Access: https://dx.doi.org/10.7488/ds/2426; https://datashare.ed.ac.uk/handle/10283/3170

Goniodysgenesis is a developmental abnormality of the anterior chamber of the eye. It is generally considered to be congenital in dogs (Canis lupus familiaris), and has been associated with glaucoma and blindness. Goniodysgenesis and early-onset glaucoma initially emerged in Border Collies in Australia in the late 1990s and has subsequently been found in Europe and the USA. The objective of the present study was to determine the genetic basis of goniodysgenesis in Border Collies. Clinical diagnosis was based on results of examinations by veterinary ophthalmologists of affected and unaffected dogs from eleven different countries. Genotyping using the Illumina high density canine SNP chip and whole genome sequencing were used to identify candidate genetic regions. Expression profiles and evolutionary conservation of candidate genes were assessed using public databases. Analysis of pedigree information was consistent with an autosomal recessive mode of inheritance for severe goniodysgenesis (potentially leading ... : The data comprise genotype data for 58 Border Collies, genotyped using the Illumina 170k CanineHD BeadChip. More details are given in the associated readme.txt file ...