Genomic characterization and virulence gene profiling of Erysipelothrix rhusiopathiae isolated from widespread muskox mortalities in the Canadian Arctic Archipelago ...
Abstract Background Muskoxen are important ecosystem components and provide food, economic opportunities, and cultural well-being for Indigenous communities in the Canadian Arctic. Between 2010 and 2021, Erysipelothrix rhusiopathiae was isolated from carcasses of muskoxen, caribou, a seal, and an Ar...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article in Journal/Newspaper |
| Language: | unknown |
| Published: |
figshare
2024
|
| Subjects: | |
| Online Access: | https://dx.doi.org/10.6084/m9.figshare.c.7348262 https://springernature.figshare.com/collections/Genomic_characterization_and_virulence_gene_profiling_of_Erysipelothrix_rhusiopathiae_isolated_from_widespread_muskox_mortalities_in_the_Canadian_Arctic_Archipelago/7348262 |
| Summary: | Abstract Background Muskoxen are important ecosystem components and provide food, economic opportunities, and cultural well-being for Indigenous communities in the Canadian Arctic. Between 2010 and 2021, Erysipelothrix rhusiopathiae was isolated from carcasses of muskoxen, caribou, a seal, and an Arctic fox during multiple large scale mortality events in the Canadian Arctic Archipelago. A single strain (‘Arctic clone’) of E. rhusiopathiae was associated with the mortalities on Banks, Victoria and Prince Patrick Islands, Northwest Territories and Nunavut, Canada (2010–2017). The objectives of this study were to (i) characterize the genomes of E. rhusiopathiae isolates obtained from more recent muskox mortalities in the Canadian Arctic in 2019 and 2021; (ii) identify and compare common virulence traits associated with the core genome and mobile genetic elements (i.e. pathogenicity islands and prophages) among Arctic clone versus other E. rhusiopathiae genomes; and iii) use pan-genome wide association studies ... |
|---|