High prevalence of diabetes among young First Nations Peoples with metabolic dysfunction-associated steatotic liver disease: a population-based study in Australia ...

• Main Authors: Valery, Patricia C., Roche, Shruti, Brown, Catherine, O’Beirne, James, Hartel, Gunter, Leggett, Barbara, Skoien, Richard, Powell, Elizabeth E.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2024
• Subjects: Medicine; Chemical Sciences not elsewhere classified; Ecology; FOS Biological sciences; Sociology; FOS Sociology; Biological Sciences not elsewhere classified; Cancer; Science Policy; Queensland; First Nations
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.7208714; https://springernature.figshare.com/collections/High_prevalence_of_diabetes_among_young_First_Nations_Peoples_with_metabolic_dysfunction-associated_steatotic_liver_disease_a_population-based_study_in_Australia/7208714

Abstract Background Liver disease is an important contributor to the mortality gap between First Nations Peoples and non-Indigenous Australian adults. Despite a high burden of metabolic comorbidities among First Nations Peoples, data about the epidemiology of metabolic dysfunction-associated steatotic liver disease (MASLD) in this population is scarce. Methods A retrospective analysis of all adults hospitalized with MASLD or metabolic dysfunction-associated steatohepatitis (MASH) with/without cirrhosis during 2007–2019 in the state of Queensland was performed. Patients were followed from the first admission with MASLD/MASH (identified based on validated algorithms) to decompensated cirrhosis and overall mortality. We explored differences according to Indigenous status using Multivariable Cox regression. Findings 439 First Nations Peoples and 7,547 non-Indigenous Australians were followed for a median of 4.6 years (interquartile range 2.7–7.2). Overall, women were overrepresented, but more so in the First ...