Polar microalgae extracts protect human HaCaT keratinocytes from damaging stimuli and ameliorate psoriatic skin inflammation in mice ...

Abstract Background Polar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our first line of defense against external threats, polar microalgae extracts may possess restorative properties for damaged skin, but the potential of microalgae e...

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Bibliographic Details
Main Authors: Lim, YoonHee, Park, So-Hyun, Kim, Eun Jae, Lim, HeeJun, Jang, Jinsun, Hong, In-Sun, Kim, Sanghee, Jung, YunJae
Format: Article in Journal/Newspaper
Language:unknown
Published: figshare 2023
Subjects:
Biochemistry
Medicine
Cell Biology
Molecular Biology
Physiology
FOS: Biological sciences
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Immunology
FOS: Clinical medicine
Biological Sciences not elsewhere classified
Developmental Biology
Arctic
Antarctic
The Antarctic
Antarc*
Online Access:https://dx.doi.org/10.6084/m9.figshare.c.6739521.v1
https://springernature.figshare.com/collections/Polar_microalgae_extracts_protect_human_HaCaT_keratinocytes_from_damaging_stimuli_and_ameliorate_psoriatic_skin_inflammation_in_mice/6739521/1
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Summary:Abstract Background Polar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our first line of defense against external threats, polar microalgae extracts may possess restorative properties for damaged skin, but the potential of microalgae extracts as skin protective agents remains unknown. Purpose This study aimed to analyze compound profiles from polar microalgae extracts, evaluate their potential as skin epithelial protective agents, and examine the underlying mechanisms. Methods Six different polar microalgae, Micractinium sp. (KSF0015 and KSF0041), Chlamydomonas sp. (KNM0029C, KSF0037, and KSF0134), and Chlorococcum sp. (KSF0003), were collected from the Antarctic or Arctic regions. Compound profiles of polar and non-polar microalgae extracts were analyzed using gas chromatography-mass spectrometry (GC-MS). The protective activities of polar microalgae extracts on human keratinocyte cell lines against oxidative stress, radiation, and psoriatic ...

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