Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations ...

• Main Authors: de Moel, Emma C., Trouw, Leendert A., Terao, Chikashi, Govind, Nimmisha, Tikly, Mohammed, El-Gabalawy, Hani, Smolik, Irene, Bang, Holger, Huizinga, Tom W. J., Toes, René E. M., van der Woude, Diane
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2023
• Subjects: Immunology; FOS Clinical medicine; Canada; First Nations
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.6590120; https://springernature.figshare.com/collections/Geo-epidemiology_of_autoantibodies_in_rheumatoid_arthritis_comparison_between_four_ethnically_diverse_populations/6590120

Abstract Background Rheumatoid arthritis (RA) occurs across the globe in different ethnic populations. Most RA patients harbor anti-modified protein antibodies (AMPA); however, it is unclear whether differences exist in autoantibody responses at different geographic locations and between different ethnic groups, which could provide new clues regarding factors underlying autoantibody development. We therefore investigated AMPA prevalence and association with HLA DRB1 alleles and smoking in four ethnically diverse populations on four different continents. Methods Anti-carbamylated (anti-CarP), anti-malondialdehyde acetaldehyde (anti-MAA), and anti-acetylated protein antibodies (anti-AcVim) IgG were determined in anti-citrullinated protein antibody-positive Dutch (NL, n = 103), Japanese (JP, n = 174), First Nations Peoples in Canada (FN, n = 100), and black South African (SA, n = 67) RA patients. Ethnicity-matched local healthy controls were used to calculate cut-offs. Risk factors associated with AMPA ...