Chromosome-length genome assembly and structural variations of the primal Basenji dog (Canis lupus familiaris) genome ...

• Main Authors: Edwards, Richard J., Field, Matt A., Ferguson, James M., Dudchenko, Olga, Keilwagen, Jens, Rosen, Benjamin D., Johnson, Gary S., Rice, Edward S., Hillier, La Deanna, Hammond, Jillian M., Towarnicki, Samuel G., Omer, Arina, Khan, Ruqayya, Skvortsova, Ksenia, Bogdanovic, Ozren, Zammit, Robert A., Aiden, Erez Lieberman, Warren, Wesley C., Ballard, J. William O.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2021
• Subjects: Medicine; Genetics; FOS Biological sciences; Evolutionary Biology; Environmental Sciences not elsewhere classified; Ecology; Biological Sciences not elsewhere classified; Canis lupus
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.5341387; https://springernature.figshare.com/collections/Chromosome-length_genome_assembly_and_structural_variations_of_the_primal_Basenji_dog_Canis_lupus_familiaris_genome/5341387

Abstract Background Basenjis are considered an ancient dog breed of central African origins that still live and hunt with tribesmen in the African Congo. Nicknamed the barkless dog, Basenjis possess unique phylogeny, geographical origins and traits, making their genome structure of great interest. The increasing number of available canid reference genomes allows us to examine the impact the choice of reference genome makes with regard to reference genome quality and breed relatedness. Results Here, we report two high quality de novo Basenji genome assemblies: a female, China (CanFam_Bas), and a male, Wags. We conduct pairwise comparisons and report structural variations between assembled genomes of three dog breeds: Basenji (CanFam_Bas), Boxer (CanFam3.1) and German Shepherd Dog (GSD) (CanFam_GSD). CanFam_Bas is superior to CanFam3.1 in terms of genome contiguity and comparable overall to the high quality CanFam_GSD assembly. By aligning short read data from 58 representative dog breeds to three reference ...