Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

• Main Authors: Lowry, Estelle, Rautio, Nina, Wasenius, Niko, Bond, Tom A., Lahti, Jari, Tzoulaki, Ioanna, Dehghan, Abbas, Heiskala, Anni, Ala-Mursula, Leena, Miettunen, Jouko, Eriksson, Johan, Marjo-Riitta Järvelin, Sebert, Sylvain
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2020
• Subjects: Medicine; Genetics; FOS Biological sciences; Biotechnology; 59999 Environmental Sciences not elsewhere classified; FOS Earth and related environmental sciences; Ecology; Sociology; FOS Sociology; 69999 Biological Sciences not elsewhere classified; Science Policy; Northern Finland
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.4983467.v1; https://springernature.figshare.com/collections/Early_exposure_to_social_disadvantages_and_later_life_body_mass_index_beyond_genetic_predisposition_in_three_generations_of_Finnish_birth_cohorts/4983467/1

Abstract Background The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. Methods We studied participants of Helsinki Birth Cohort Study born in 1934–1944 (HBCS1934–1944, n = 1277) and Northern Finland Birth Cohorts born in 1966 and 1986 (NFBC1966, n = 5807, NFBC1986, n = 6717). Factor analysis produced scores of social disadvantage based on social and economic elements in early life and adulthood/over the life course, and was categorized as high, intermediate and low. BMI was measured at 62 years in HBCS1934–1944, at 46 years in NFBC1966 and at 16 years in NFBC1986. Multivariable linear regression analysis was used to explore associations between social disadvantages and BMI after adjustments for polygenic risk score for BMI (PRS BMI), maternal BMI and sex. Results The association between exposure to high early social disadvantage and increased later life BMI persisted after adjustments (β = 0.79, 95% CI, 0.33, 1.25, p