Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

Abstract Background The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. Methods We studied participants of Helsinki Birth Cohort Study born in 1934–1...

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Bibliographic Details
Main Authors: Lowry, Estelle, Rautio, Nina, Wasenius, Niko, Bond, Tom A., Lahti, Jari, Tzoulaki, Ioanna, Dehghan, Abbas, Heiskala, Anni, Ala-Mursula, Leena, Miettunen, Jouko, Eriksson, Johan, Marjo-Riitta Järvelin, Sebert, Sylvain
Format: Article in Journal/Newspaper
Language:unknown
Published: figshare 2020
Subjects:
Medicine
Genetics
FOS Biological sciences
Biotechnology
59999 Environmental Sciences not elsewhere classified
FOS Earth and related environmental sciences
Ecology
Sociology
FOS Sociology
69999 Biological Sciences not elsewhere classified
Science Policy
Northern Finland
Online Access:https://dx.doi.org/10.6084/m9.figshare.c.4983467.v1
https://springernature.figshare.com/collections/Early_exposure_to_social_disadvantages_and_later_life_body_mass_index_beyond_genetic_predisposition_in_three_generations_of_Finnish_birth_cohorts/4983467/1
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Summary:Abstract Background The study aimed to explore the association between early life and life-course exposure to social disadvantage and later life body mass index (BMI) accounting for genetic predisposition and maternal BMI. Methods We studied participants of Helsinki Birth Cohort Study born in 1934–1944 (HBCS1934–1944, n = 1277) and Northern Finland Birth Cohorts born in 1966 and 1986 (NFBC1966, n = 5807, NFBC1986, n = 6717). Factor analysis produced scores of social disadvantage based on social and economic elements in early life and adulthood/over the life course, and was categorized as high, intermediate and low. BMI was measured at 62 years in HBCS1934–1944, at 46 years in NFBC1966 and at 16 years in NFBC1986. Multivariable linear regression analysis was used to explore associations between social disadvantages and BMI after adjustments for polygenic risk score for BMI (PRS BMI), maternal BMI and sex. Results The association between exposure to high early social disadvantage and increased later life BMI persisted after adjustments (β = 0.79, 95% CI, 0.33, 1.25, p

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