Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study
Abstract Background Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a...
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ftdatacite:10.6084/m9.figshare.c.4663289.v1 2023-05-15T18:34:55+02:00 Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study J. Aviles-Solis C. Jácome A. Davidsen R. Einarsen S. Vanbelle H. Pasterkamp H. Melbye 2019 https://dx.doi.org/10.6084/m9.figshare.c.4663289.v1 https://springernature.figshare.com/collections/Prevalence_and_clinical_associations_of_wheezes_and_crackles_in_the_general_population_the_Troms_study/4663289/1 unknown figshare https://dx.doi.org/10.1186/s12890-019-0928-1 https://dx.doi.org/10.6084/m9.figshare.c.4663289 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 CC-BY Medicine Biotechnology Immunology FOS Clinical medicine 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Cancer Collection article 2019 ftdatacite https://doi.org/10.6084/m9.figshare.c.4663289.v1 https://doi.org/10.1186/s12890-019-0928-1 https://doi.org/10.6084/m9.figshare.c.4663289 2021-11-05T12:55:41Z Abstract Background Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a large general adult population and explore associations with self-reported disease, smoking status and lung function. Methods We recorded lung sounds in 4033 individuals 40 years or older and collected information on self-reported disease. Pulse oximetry and spirometry were carried out. We estimated age-standardized prevalence of wheezes and crackles and associations between wheezes and crackles and variables of interest were analyzed with univariable and multivariable logistic regressions. Results Twenty-eight percent of individuals had wheezes or crackles. The age-standardized prevalence of wheezes was 18.6% in women and 15.3% in men, and of crackles, 10.8 and 9.4%, respectively. Wheezes were mostly found during expiration and crackles during inspiration. Significant predictors of expiratory wheezes in multivariable analyses were age (10 years increase - OR 1.18, 95%CI 1.09–1.30), female gender (1.45, 1.2–1.8), self-reported asthma (1.36, 1.00–1.83), and current smoking (1.70, 1.28–2.23). The most important predictors of inspiratory crackles were age (1.76, 1.57–1.99), current smoking, (1.94, 1.40–2.69), mMRC ≥2 (1.79, 1.18–2.65), SpO2 (0.88, 0.81–0.96), and FEV1 Z-score (0.86, 0.77–0.95). Conclusions Nearly over a quarter of adults present adventitious lung sounds on auscultation. Age was the most important predictor of adventitious sounds, particularly crackles. The adventitious sounds were also associated with self-reported disease, current smoking and measures of lung function. The presence of findings in two or more auscultation sites was associated with a higher risk of decreased lung function than solitary findings. Article in Journal/Newspaper Tromsø DataCite Metadata Store (German National Library of Science and Technology) Tromsø |
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DataCite Metadata Store (German National Library of Science and Technology) |
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language |
unknown |
topic |
Medicine Biotechnology Immunology FOS Clinical medicine 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Cancer |
spellingShingle |
Medicine Biotechnology Immunology FOS Clinical medicine 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Cancer J. Aviles-Solis C. Jácome A. Davidsen R. Einarsen S. Vanbelle H. Pasterkamp H. Melbye Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
topic_facet |
Medicine Biotechnology Immunology FOS Clinical medicine 19999 Mathematical Sciences not elsewhere classified FOS Mathematics Cancer |
description |
Abstract Background Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a large general adult population and explore associations with self-reported disease, smoking status and lung function. Methods We recorded lung sounds in 4033 individuals 40 years or older and collected information on self-reported disease. Pulse oximetry and spirometry were carried out. We estimated age-standardized prevalence of wheezes and crackles and associations between wheezes and crackles and variables of interest were analyzed with univariable and multivariable logistic regressions. Results Twenty-eight percent of individuals had wheezes or crackles. The age-standardized prevalence of wheezes was 18.6% in women and 15.3% in men, and of crackles, 10.8 and 9.4%, respectively. Wheezes were mostly found during expiration and crackles during inspiration. Significant predictors of expiratory wheezes in multivariable analyses were age (10 years increase - OR 1.18, 95%CI 1.09–1.30), female gender (1.45, 1.2–1.8), self-reported asthma (1.36, 1.00–1.83), and current smoking (1.70, 1.28–2.23). The most important predictors of inspiratory crackles were age (1.76, 1.57–1.99), current smoking, (1.94, 1.40–2.69), mMRC ≥2 (1.79, 1.18–2.65), SpO2 (0.88, 0.81–0.96), and FEV1 Z-score (0.86, 0.77–0.95). Conclusions Nearly over a quarter of adults present adventitious lung sounds on auscultation. Age was the most important predictor of adventitious sounds, particularly crackles. The adventitious sounds were also associated with self-reported disease, current smoking and measures of lung function. The presence of findings in two or more auscultation sites was associated with a higher risk of decreased lung function than solitary findings. |
format |
Article in Journal/Newspaper |
author |
J. Aviles-Solis C. Jácome A. Davidsen R. Einarsen S. Vanbelle H. Pasterkamp H. Melbye |
author_facet |
J. Aviles-Solis C. Jácome A. Davidsen R. Einarsen S. Vanbelle H. Pasterkamp H. Melbye |
author_sort |
J. Aviles-Solis |
title |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_short |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_full |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_fullStr |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_full_unstemmed |
Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study |
title_sort |
prevalence and clinical associations of wheezes and crackles in the general population: the tromsø study |
publisher |
figshare |
publishDate |
2019 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.4663289.v1 https://springernature.figshare.com/collections/Prevalence_and_clinical_associations_of_wheezes_and_crackles_in_the_general_population_the_Troms_study/4663289/1 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://dx.doi.org/10.1186/s12890-019-0928-1 https://dx.doi.org/10.6084/m9.figshare.c.4663289 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.4663289.v1 https://doi.org/10.1186/s12890-019-0928-1 https://doi.org/10.6084/m9.figshare.c.4663289 |
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1766219921903058944 |