Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes ...

• Main Authors: Lofterød, Trygve, Mortensen, Elin, Nalwoga, Hawa, Wilsgaard, Tom, Frydenberg, Hanne, Risberg, Terje, Eggen, Anne, McTiernan, Anne, Aziz, Sura, Wist, Erik, Stensvold, Andreas, Reitan, Jon, Akslen, Lars, Thune, Inger
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2018
• Subjects: Medicine; Genetics; FOS: Biological sciences; Biological Sciences not elsewhere classified; Cancer; Plant Biology; Tromsø
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.4134797; https://springernature.figshare.com/collections/Impact_of_pre-diagnostic_triglycerides_and_HDL-cholesterol_on_breast_cancer_recurrence_and_survival_by_breast_cancer_subtypes/4134797

Abstract Background High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear. Methods A population-based survival study among 464 breast cancer cases identified within the Tromsø study was conducted. Pre-diagnostic triglycerides, total-cholesterol and HDL-cholesterol were measured, and detailed clinical and histopathological data were obtained. Using tissue microarray, all breast cancer cases were reclassified into the following subtypes: Luminal A, Luminal B, HER2-enriched, and triple negative breast cancer (TNBC). Multivariable Cox proportional hazards regression models were used to study the associations between pre-diagnostic lipids and breast cancer recurrence, mortality, and survival. Results A total of 464 breast cancer patients, with mean age at diagnosis of 57.9 years, ...