Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes ...
Abstract Background High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
figshare
2018
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Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.c.4134797 https://springernature.figshare.com/collections/Impact_of_pre-diagnostic_triglycerides_and_HDL-cholesterol_on_breast_cancer_recurrence_and_survival_by_breast_cancer_subtypes/4134797 |
Summary: | Abstract Background High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear. Methods A population-based survival study among 464 breast cancer cases identified within the Tromsø study was conducted. Pre-diagnostic triglycerides, total-cholesterol and HDL-cholesterol were measured, and detailed clinical and histopathological data were obtained. Using tissue microarray, all breast cancer cases were reclassified into the following subtypes: Luminal A, Luminal B, HER2-enriched, and triple negative breast cancer (TNBC). Multivariable Cox proportional hazards regression models were used to study the associations between pre-diagnostic lipids and breast cancer recurrence, mortality, and survival. Results A total of 464 breast cancer patients, with mean age at diagnosis of 57.9 years, ... |
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