Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease

Abstract Background Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to identify new and previously known genetic variants in a set of candida...

Full description

Bibliographic Details
Main Authors: Matsson, Hans, Söderhäll, Cilla, Einarsdottir, Elisabet, Lamontagne, Maxime, Gudmundsson, Sanna, Backman, Helena, Lindberg, Anne, Rönmark, Eva, Kere, Juha, Sin, Don, Postma, Dirkje, Yohan Bossé, Lundbäck, Bo, Klar, Joakim
Format: Article in Journal/Newspaper
Language:unknown
Published: Figshare 2016
Subjects:
Medicine
Genetics
FOS Biological sciences
Molecular Biology
69999 Biological Sciences not elsewhere classified
Cancer
111714 Mental Health
FOS Health sciences
110309 Infectious Diseases
60506 Virology
Northern Sweden
Online Access:https://dx.doi.org/10.6084/m9.figshare.c.3621659.v1
https://figshare.com/collections/Targeted_high-throughput_sequencing_of_candidate_genes_for_chronic_obstructive_pulmonary_disease/3621659/1
Description
Summary:Abstract Background Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to identify new and previously known genetic variants in a set of candidate genes for COPD. Methods Exons in 22 genes implicated in lung development as well as 61 genes and 10 genomic regions previously associated with COPD were sequenced using individual DNA samples from 68 cases with moderate or severe COPD and 66 controls matched for age, gender and smoking. Cases and controls were selected from the Obstructive Lung Disease in Northern Sweden (OLIN) studies. Results In total, 37 genetic variants showed association with COPD (p

Similar Items