An evolutionary divergent pestivirus lacking the N pro gene systemically infects a whale species ...
Pestiviruses typically infect members of the order Artiodactyla, including ruminants and pigs, although putative rat and bat pestiviruses have also been described. In the present study, we identified and characterized an evolutionary divergent pestivirus in the toothed whale species, harbour porpois...
| Main Authors: | , , , , , , , , , |
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| Format: | Text |
| Language: | unknown |
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Taylor & Francis
2019
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| Online Access: | https://dx.doi.org/10.6084/m9.figshare.9864062.v1 https://tandf.figshare.com/articles/journal_contribution/An_evolutionary_divergent_pestivirus_lacking_the_N_sup_pro_sup_gene_systemically_infects_a_whale_species/9864062/1 |
| Summary: | Pestiviruses typically infect members of the order Artiodactyla, including ruminants and pigs, although putative rat and bat pestiviruses have also been described. In the present study, we identified and characterized an evolutionary divergent pestivirus in the toothed whale species, harbour porpoise ( Phocoena phocoena ). We tentatively named the virus Phocoena pestivirus (PhoPeV). PhoPeV displays a typical pestivirus genome organization except for the unique absence of N pro , an N-terminal autoprotease that targets the innate host immune response. Evolutionary evidence indicates that PhoPeV emerged following an interspecies transmission event from an ancestral pestivirus that expressed N pro . We show that 9% ( n = 10) of stranded porpoises from the Dutch North Sea coast ( n = 112) were positive for PhoPeV and they displayed a systemic infection reminiscent of non-cytopathogenic persistent pestivirus infection. The identification of PhoPeV extends the host range of pestiviruses to cetaceans (dolphins, ... |
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