Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods ...

Ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corr...

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Bibliographic Details
Main Authors: Ding, Jing, Yang, Zhijun, Zhao, Yu, Fang, Weizhen, Lu, Qun
Format: Text
Language:unknown
Published: Taylor & Francis 2019
Subjects:
Biophysics
Biochemistry
Microbiology
FOS Biological sciences
Genetics
Biotechnology
Chemical Sciences not elsewhere classified
Infectious Diseases
FOS Health sciences
Antarc*
Antarctica
Online Access:https://dx.doi.org/10.6084/m9.figshare.7604639.v1
https://tandf.figshare.com/articles/journal_contribution/Lipase-catalyzed_synthesis_of_ethyl_i_R_i_-2-benzyloxy-2-isopropylhydrogenmalonate_a_useful_combination_of_chemical_synthesis_with_enzymatic_methods/7604639/1
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Summary:Ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester. Novozyme 435 catalyzed hydrolysis reaction to prepare the key intermediate for the synthesis of peptide side chain of ergopeptides. ...

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