Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086

• Main Authors: Cong-Cong Liu, Zhang, Zhen-Zhen, Feng, Yan-Yan, Qian-Qun Gu, Li, De-Hai, Zhu, Tian-Jiao
• Format: Text
• Language: unknown
• Published: Taylor & Francis 2018
• Subjects: Biochemistry; Microbiology; FOS Biological sciences; Neuroscience; Pharmacology; 59999 Environmental Sciences not elsewhere classified; FOS Earth and related environmental sciences; 39999 Chemical Sciences not elsewhere classified; FOS Chemical sciences; Ecology; Inorganic Chemistry; Plant Biology; 60506 Virology; Antarctic; The Antarctic; Antarc*
• Online Access: https://dx.doi.org/10.6084/m9.figshare.6067418; https://tandf.figshare.com/articles/Secondary_metabolites_from_Antarctic_marine-derived_fungus_i_Penicillium_crustosum_i_HDN153086/6067418

A new polyene compound ( 1 ) and a new diketopiperazine ( 2 ), as well as three known compounds ( 3 – 5 ), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1 – 5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC 50 value of 12.7 μM.