Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086
A new polyene compound ( 1 ) and a new diketopiperazine ( 2 ), as well as three known compounds ( 3 – 5 ), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1 – 5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. Th...
Main Authors: | , , , , , |
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Format: | Text |
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Taylor & Francis
2018
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Online Access: | https://dx.doi.org/10.6084/m9.figshare.6067418 https://tandf.figshare.com/articles/Secondary_metabolites_from_Antarctic_marine-derived_fungus_i_Penicillium_crustosum_i_HDN153086/6067418 |
Summary: | A new polyene compound ( 1 ) and a new diketopiperazine ( 2 ), as well as three known compounds ( 3 – 5 ), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1 – 5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC 50 value of 12.7 μM. |
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