Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18 ...

A new furanone derivative, butanolide A ( 1 ), and a new sesquiterpene, guignarderemophilane F ( 2 ), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-...

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Bibliographic Details
Main Authors: Zhou, Yue, Li, Yun-Hai, Yu, Hao-Bing, Liu, Xiao-Yu, Lu, Xiao-Ling, Jiao, Bing-Hua
Format: Text
Language:unknown
Published: Taylor & Francis 2017
Subjects:
Biochemistry
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Sociology
FOS Sociology
Biological Sciences not elsewhere classified
Inorganic Chemistry
FOS Chemical sciences
Antarctic
Antarc*
Online Access:https://dx.doi.org/10.6084/m9.figshare.5481388.v1
https://tandf.figshare.com/articles/journal_contribution/Furanone_derivative_and_sesquiterpene_from_Antarctic_marine-derived_fungus_i_Penicillium_i_sp_S-1-18/5481388/1
Description
Summary:A new furanone derivative, butanolide A ( 1 ), and a new sesquiterpene, guignarderemophilane F ( 2 ), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses. The absolute configuration of 1 was determined by the modified Mosher’s method, while the absolute configuration of 2 was determined by calculated ECD spectroscopy. The isolated secondary metabolites were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compound 1 showed moderate inhibitory activity against PTP1B with IC 50 value of 27.4 μM. ...

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