Antibacterial constituents from Antarctic fungus, Aspergillus sydowii SP-1 ...

One new alkaloid, named as acremolin C ( 1 ), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation of the antimicrobial constituents of this Antarctic microorganism, and its structure was determined by spectroscopic methods. Additionally, four known com...

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Bibliographic Details
Main Authors: Li, Wen-ting, Luo, Dan, Huang, Jia-ning, Wang, Lin-lin, Zhang, Feng-guo, Xi, Tao, Liao, Jian-min, Lu, Yuan-yuan
Format: Text
Language:unknown
Published: Taylor & Francis 2017
Subjects:
Biochemistry
Medicine
Microbiology
FOS Biological sciences
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Hematology
Infectious Diseases
FOS Health sciences
Antarc*
Antarctic
Online Access:https://dx.doi.org/10.6084/m9.figshare.5100157.v1
https://figshare.com/articles/Antibacterial_constituents_from_Antarctic_fungus_i_Aspergillus_sydowii_i_SP-1/5100157/1
Description
Summary:One new alkaloid, named as acremolin C ( 1 ), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation of the antimicrobial constituents of this Antarctic microorganism, and its structure was determined by spectroscopic methods. Additionally, four known compounds, cyclo -( L -Trp- L -Phe) ( 2 ), 4-hydroxyphenylacetic acid ( 3 ), (7 S )-(+)-hydroxysydonic acid ( 4 ) and (7 S , 11 S )-(+)-12-hydroxysydonic acid ( 5 ), were isolated and identified. Biological studies disclosed that compounds 2 , 4 and 5 showed moderate inhibitions against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) as comparing to tigecycline, while compound 1 displayed weak inhibition activities against MRSA and MRSE. ...

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