Biliary tract malignancies: a population-based study on incidence, prognosis and management of patients

Background: Biliary tract malignancies are uncommon and few population-based studies are available. Methods: This nationwide population-based study in Iceland included all patients diagnosed with intra- and extrahepatic cholangiocarcinoma, gallbladder and ampullary cancer from 1984 to 2012. Patients...

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Bibliographic Details
Main Authors: Juliusson, Gunnar, Jonasson, Jon Gunnlaugur, Jonsdottir, Sara B., Garcia, Henrik G., Elinborg Olafsdottir, Pall Helgi Möller, Björnsson, Einar S.
Format: Text
Language:unknown
Published: Taylor & Francis 2016
Subjects:
Medicine
Biotechnology
59999 Environmental Sciences not elsewhere classified
FOS Earth and related environmental sciences
Ecology
FOS Biological sciences
Immunology
FOS Clinical medicine
69999 Biological Sciences not elsewhere classified
19999 Mathematical Sciences not elsewhere classified
FOS Mathematics
Cancer
Science Policy
Iceland
Online Access:https://dx.doi.org/10.6084/m9.figshare.3753573
https://tandf.figshare.com/articles/journal_contribution/Biliary_tract_malignancies_a_population-based_study_on_incidence_prognosis_and_management_of_patients/3753573
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Summary:Background: Biliary tract malignancies are uncommon and few population-based studies are available. Methods: This nationwide population-based study in Iceland included all patients diagnosed with intra- and extrahepatic cholangiocarcinoma, gallbladder and ampullary cancer from 1984 to 2012. Patients were identified through the Icelandic Cancer Registry. Clinical information was obtained from patient records. Results: Overall 245 patients were identified: 38 had intrahepatic cholangiocarcinoma, 66 extrahepatic cholangiocarcinoma, 73 gallbladder cancer (GBC) and 68 ampullary cancer. Overall incidence for bile tract malignancies was 1–3 per 100,000 person-years and less than 1 by sub-type. The overall bile tract malignancies in males increased from 1.3 (95% CI 0.8–1.8) to 2.5 (1.9–3.1) per 100,000 inhabitants. The incidence of GBC among females decreased from 1.1 (0.7–1.5) to 0.5 (0.2–0.7). Surgery decreased for extrahepatic cholangiocarcinoma (56 to 23%, p = .027), ampullary cancer (80 to 48%, p = .03) and overall bile tract cancer (61 to 32%, p p Conclusions: Overall incidence of bile tract malignancies increased in males and GBC decreased in women. Long-term survival is poor and did not improve despite changes in treatment.

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