Chemoenzymatic formal synthesis of (+)-brazilin ...

Herein, the manuscript presents a chemoenzymatic formal synthetic route of (+)-brazilin, a homoisoflavonoid natural product with a chroman skeleton cis-fused with a 2,3-dihydro-1 H -indene unit, which is isolated from the traditional Chinese medicine, Caesalpinia sappan L . The key feature of the sy...

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Bibliographic Details
Main Authors: Liu, Jiangtao, Han, Xue, Yu, Liuping, Zhang, Jiandong, Huang, Shuangping, Yang, Xihua, Chang, Honghong
Format: Text
Language:unknown
Published: Taylor & Francis 2024
Subjects:
Biochemistry
Genetics
FOS Biological sciences
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Ecology
Antarc*
Antarctica
Online Access:https://dx.doi.org/10.6084/m9.figshare.25764548
https://tandf.figshare.com/articles/journal_contribution/Chemoenzymatic_formal_synthesis_of_-brazilin/25764548
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Summary:Herein, the manuscript presents a chemoenzymatic formal synthetic route of (+)-brazilin, a homoisoflavonoid natural product with a chroman skeleton cis-fused with a 2,3-dihydro-1 H -indene unit, which is isolated from the traditional Chinese medicine, Caesalpinia sappan L . The key feature of the synthetic strategy includes an enzyme-mediated desymmetrization by employing lipase from Candida antarctica type B (CALB) and a one-pot S N 2/hydrolysis reaction. ...

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